Sometimes you just need a little DNS to get you through your day.
This is an 18 minute video that goes through the configuration of Route 53 both at Dreamhost (my service provider) and Amazon Web Services. The setup is fairly straight forward with little to no hitches when setting up the system.
The main thing to remember is to have your service provider setup ready to go if you are using a freshly registered domain name. You have to make sure you zone file is set up on the registrar side, and you need to be patient, it could take up to 24 hours for all the changes to go through and be able to get to the system via DNS.
Route 53 is a really nice setup if you want to run some custom domain names for your system. Especially when you can set the domains up for fail over and weighted so that if service is failing in one AWS zone it can fail over to another AWS zone via health checks.
In all this is something you really do want to explore if you are interested in setting up DNS zones or just DNS to run off your AWS instances rather than using the standard public DNS. You will need to lease an IP address from Amazon, so make sure you can lease the IP addresses you need. The standard amount of leases is generally five IP addresses, so if you need or want more, you will have to request that from Amazon to increase your limit.